A microbiota derived metabolite and pediatric celiac disease pathogenesis

(P558)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 558
Abstract ID: 4966

Presenting Author:
Kristina Kelley, Boston Col.

Co-Authors:
Khyati Girdhar, Boston Col.; Yusuf Dogus Dogru, Boston Col.; Yi Yang, Yale Sch. of Med.; Vladimir Tolstikov, Yale Sch. of Med.; Michael A Kiebish, BPGBio; Noah W Palm, Yale Sch. of Med.; Johnny Ludvigsson, Crown Princess Victoria's Children and Youth Hosp., Linköping Univ. Hosp.; Genesis Soto, Boston Col.; Michelle Zhang, Boston Col.; Emrah Altindis, Boston Col.;

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Secondary hemophagocytic lymphohistiocytosis with associated central pontine myelinolysis

(P560)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 560
Abstract ID: 6149

Presenting Author:
Rachel Philip, Rocky Vista Univ.

Co-Author:
Mariam Alam, Rocky Vista Univ.;

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Amplified STAT3 increases expression of the CD39 ectoenzyme and impairs function of CD8⁺ T cells.

(P568)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 568
Abstract ID: 6275

Presenting Author:
Jose S. Campos Duran, Univ. of Pennsylvania Perelman Sch. of Med., Children's Hosp. of Philadelphia

Co-Authors:
Samir Sayed, Children's Hosp. of Philadelphia; Montana Knight, Children's Hosp. of Philadelphia; Megan C. Dalalo, Univ. of Pennsylvania; Peyton E. Conrey, Children's Hosp. of Philadelphia; Ceire A. Hay, Children's Hosp. of Philadelphia; Erica G. Schmitt, Washington Univ., St. Louis; Martin Thelin, UCSF; Andrea A. Mauracher, Children's Hosp. of Philadelphia; Lisa R. Forbes, Baylor Col. of Med.; Steven M. Holland, NIAID, NIH; Jenna R.E. Bergerson, NIAID, NIH; Helen C. Su, NIAID, NIH; Neil D. Romberg, Children's Hosp. of Philadelphia; Alexandra F. Freeman, NIAID, NIH; Jennifer W. Leiding, Johns Hopkins Univ.; Mark S. Anderson, UCSF; Megan A. Cooper, Washington Univ., St. Louis; Tiphanie P. Vogel, Baylor Col. of Med.; Sarah E. Henrickson, Children's Hosp. of Philadelphia;

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Rheumatoid arthritis synovial fibroblast modulation of T cell activation

(P570)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 570
Abstract ID: 6493

Presenting Author:
Melissa Romoff, Hosp. for Special Surgery, Weill Cornell Medical College

Co-Authors:
Vianne R Gao, Mem. Sloan Kettering Cancer Ctr.; Edward F DiCarlo, Hosp. for Special Surgery; Daniel C Ramirez, Hosp. for Special Surgery; Susan M Goodman, Hosp. for Special Surgery; Thomas M Norman, Mem. Sloan Kettering Cancer Ctr.; Christina S Leslie, Mem. Sloan Kettering Cancer Ctr.; Alexander Y Rudensky, Mem. Sloan Kettering Cancer Ctr.; Laura T Donlin, Weill Cornell Med. Col.; Melanie H Smith, Hosp. for Special Surgery;

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Spatial Molecular Profiling of the Kidney of Children with Lupus Nephritis

(P574)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 574
Abstract ID: 7340

Presenting Author:
Juan F Rodriguez-Alcazar, Weill Cornell Med.

Co-Authors:
Uthra Balaji, Weill Cornell Med.; Leanna Troncoso, Icahn Sch. of Med., Mount Sinai; Amanda Reid, Icahn Sch. of Med., Mount Sinai; Pauline Hamon, Icahn Sch. of Med., Mount Sinai; Sean Houghton, Weill Cornell Med.; Lynnette Walters, Scottish Rite for Children, Dallas; Cynthia Smitherman, Weill Cornell Med.; Jeanine Baisch, Weill Cornell Med.; Marina L S Santos, Weill Cornell Med.; Owen Larosiliere, Weill Cornell Med.; Lauren Robinson, Hospital for Special Surgery; Tracey Wright, Scottish Rite for Children, Dallas; Miriam Merad, Icahn Sch. of Med., Mount Sinai; Simone Caielli, Weill Cornell Med.; Jinghua Gu, Weill Cornell Med.; Virginia Pascual, Weill Cornell Med.;

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Recombinant human C1 inhibitor improves acute cardiac function and attenuates acute myocarditis after traumatic brain injury and hemorrhagic shock in swine

(P578)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 578
Abstract ID: 7628

Presenting Author:
Yansong Li, UT Hlth. San Antonio Long Sch. of Med.

Co-Authors:
Yansheng Feng, Geneva Fndn.; Milomir Simovic, Geneva Fndn.; Amy Kim, Geneva Fndn.; Gabriel Jeppson, Geneva Fndn.; Chelsea Halcomb, Geneva Fndn.; Ebony Griffin, UT Hlth. San Antonio Long Sch. of Med.; Isai Garza-Chapa, UT Hlth. San Antonio Long Sch. of Med.; Katie Strychalski, UT Hlth. San Antonio Long Sch. of Med.; Yolanda Ponstein, Pharming Group; Jacqueline Illario, UT Hlth. San Antonio Long Sch. of Med.; Tatiana Corey, UT Hlth. San Antonio Long Sch. of Med.; Sander Hacker, UT Hlth. San Antonio Long Sch. of Med.; James Elliott, UT Hlth. San Antonio Long Sch. of Med.; Leopoldo Cancio, U.S. Army Inst. of Surgical Res.; James Bynum, UT Hlth. San Antonio Long Sch. of Med.;

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Novel autoantibody targets distinguish Multisystem Inflammatory Syndrome in Children (MIS-C) from other febrile children, including those with Kawasaki Disease (KD)

(P580)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 580
Abstract ID: 7668

Presenting Author:
Devin Decotes, Univ. at Buffalo Jacobs Sch. of Med. and Biomed. Sci., SUNY

Co-Author:
Mark D Hicar, Univ. at Buffalo Jacobs Sch. of Med. and Biomed. Sci., SUNY;

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Infection of the human lymphoid organ on-a-chip with Borrelia burgdorferi reveals novel mechanisms of immunosuppression and autoimmunity in Lyme disease

(P582)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 582
Abstract ID: 7687

Presenting Author:
Girija Goyal, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.

Co-Authors:
Min Wen Ku, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Yunhao Zhai, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Kavya Menon, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Demi Laforest, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Russell Gould, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Aakanksha Gulati, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Marina Feigenson, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Jessica F Feitor, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Shad R Morton, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Nandhinee R Shanmugam, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Rohini Singh, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Aditya P Patil, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Pranav Prabhala, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Supriya Gharpure, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Viktor Horvath, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Abdul R Isaacs, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Pawan Jolly, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Bogdan Budnik, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.; Donald E Ingber, Wyss Inst. for Bio. Inspired Engr. at Harvard Univ.;

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Profound B cell dysregulation in idiopathic multicentric Castleman disease

(P586)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 586
Abstract ID: 7872

Presenting Author:
MELANIE MUMAU, Univ. of Pennsylvania Perelman Sch. of Med.

Co-Authors:
M. Betina Pampena, Univ. of Pennsylvania Perelman Sch. of Med.; Michael V. Gonzalez, Univ. of Pennsylvania Perelman Sch. of Med.; Michael R. Betts, Univ. of Pennsylvania Perelman Sch. of Med.; David C. Fajgenbaum, Univ. of Pennsylvania Perelman Sch. of Med.;

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Correlates of susceptibility in household influenza studies 

(P588)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 588
Abstract ID: 7930

Presenting Author:
Deryn G. St. James, St. Jude Children’s Res. Hosp., Univ. of Tennessee Hlth. Sci.Ctr.

Co-Authors:
Aisha Souquette, St. Jude Children’s Res. Hosp.; Robert Mettelman, St. Jude Children’s Res. Hosp.; Lee-Ann Van de Velde, St. Jude Children’s Res. Hosp.; Taylor L. Wilson, St. Jude Children’s Res. Hosp.; Kasi Vegesana, St. Jude Children’s Res. Hosp.; E. Kaitlynn Allen, St. Jude Children’s Res. Hosp.; Joshua G. Petrie, Univ. of Michigan Sch. of Pub. Hlth; Aubree Gordon, Univ. of Michigan Sch. of Pub. Hlth; Emily Martin, Univ. of Michigan; Arnold Monto, Univ. of Michigan; Paul G. Thomas, St. Jude Children’s Res. Hosp.;

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COMPOUND 1 is a first-in-class small molecule cGAMP competitive oral STING antagonist that reduces lung inflammation and fibrosis in chronic bleomycin and silica mouse models

(P590)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 590
Abstract ID: 7950

Presenting Author:
Monali Banerjee, Curadev

Co-Authors:
Sandip Middya, Curadev; Ritesh Shrivastava, Curadev; Sourav Basu, Curadev; Rajib Ghosh, Curadev; Anindita Middya, Curadev; Nagaswamy Mane, Curadev; Priti Sharma, Curadev; Nidhi Rawat, Curadev; Thanilsana Soram, Curadev; Rubeena Rais Mansuri, Curadev; Dharmendra Yadav, Curadev; Anuj Gautam, Curadev; Vaibhav Shinde, Curadev; Manisha Padaliya, Curadev; Shahnaj Bano, Curadev; Sneha Roy, Curadev; Kavita Puniya, Curadev; David C Pryde, Curadev; Arjun Surya, Curadev;

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COMPOUND 2 is a first-in-class small molecule cGAMP competitive oral STING antagonist that reduces neuroinflammation in mouse models

(P592)

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Presentation Time: 02:15 PM–03:30 PM
Posterboard Number: 592
Abstract ID: 7981

Presenting Author:
Monali Banerjee, Curadev, Curadev

Co-Authors:
Ritesh Shrivastava, Curadev; Sandip Middya, Curadev; Sourav Basu, Curadev; Anindita Middya, Curadev; Vaibhav Shinde, Curadev; Rajib Ghosh, Curadev; Manisha Padaliya, Curadev; Shahnaj Bano, Curadev; Rubeena R Mansuri, Curadev; Priti Sharma, Curadev; Sneha Roy, Curadev; Thanilsana Soram, Curadev; Dharmendra Yadav, Curadev; Kavita Puniya, Curadev; Anuj Gautam, Curadev; David C Pryde, Curadev; Arjun Surya, Curadev;

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