SLE is a chronic autoimmune disease with a varying clinical course and prognosis. Genetic predisposition and environmental factors such as obesity contribute to lupus pathogenesis. Our published study showed that high fat diet exacerbated lupus development and autoimmunity in MRL/lpr lupus prone mice. Here we investigated the immunological and clinical features in obese and non-obese lupus patients. AI software Deep6 was used for query building resulting in 127 SLE patients in 2022, with 86 being obese (BMI>30) and 41 being non-obese (BMI<25). Their demographics, immunological and clinical parameters were extracted from EPIC and compared. Statistical significance was determined by Student’s t-test or Chi’s squared test. We found that 49% of lupus patients were obese with a significantly higher ratio of total cholesterol/HDL and higher triglyceride level, in comparing to the 21% of non-obese lupus patients. Although there was no difference in SLEDAI and CRP, anti-dsDNA titer, C3 and C4 levels were significantly increased in obese lupus patients. Significantly increased incidence of lupus nephritis and higher creatinine level were found in obese patients. Our results showed that obese lupus patients had distinct dysfunctional immunological features with worse outcomes, indicating that obesity may induce inflammation and dysfunction of immune system contributing to SLE pathogenesis. Further study may provide better preventive and treatment strategies for obese lupus patients.
The impact of obesity on immunological and clinical features in systemic lupus erythematosus
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Date: May 4 Presentation Time: 03:15 PM to 04:30 PM Room: Exhibit Hall F1