Presenting Author: Sangwon V Kim
, Assistant Professor at Thomas Jefferson Univ., Kimmel Cancer Ctr., Jefferson Hlth.
Abstract:
Chromosome 10 open reading frame 99 (C10ORF99) is the homing ligand for G-protein coupled receptor 15 (GPR15) and is expressed in blood endothelial cells to facilitate the T cell extravasation to the lamina propria of the colon. Here, we showed that, in addition to its role as a GPR15 ligand, C10ORF99 also modulates colonic epithelial cell regeneration. We found that C10ORF99 is constitutively expressed in colonic epithelial cells. Mice lacking C10ORF99 exhibited longer intestinal crypts and a higher rate of colonic epithelial cell proliferation, which made them resistant to chemically induced colitis. Additionally, colonic organoid culture showed that enhanced cell proliferation in the absence of C10ORF99 is a cell-autonomous phenotype unrelated to immune cells or gut microbiota. Therefore, we hypothesize that C10ORF99 is a novel tumor suppressor for the colonic epithelial barrier.
C10ORF99: A novel colon epithelial barrier modulator
Category
Poster and Podium (Block Symposium)
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Date: May 5 Presentation Time: 03:15 PM to 04:30 PM Room: Exhibit Hall F1