Exploring the immunomodulatory potential of Natures Immuno: A study on a mushroom formulation in alleviating LPS-induced inflammation.

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Presentation Time: 03:15 PM - 04:30 PM
Poster Board Number: B866
Abstract ID: 5569

Presenting Author:
Amanda Nascimento , Post-Doctoral Follow at Univ. of Saskatchewan

Abstract:

Introduction: Inflammatory diseases, such as pulmonary inflammation, lung cancer, and asthma, pose a significant global economic impact, affecting health and quality of life. Proinflammatory cytokines released by the immune system can be activated by Lipopolysaccharides (LPS), an endotoxin mimicking infection by Gram-negative bacteria. Literature suggests an increased risk of inflammatory diseases in females compared to males. Natures Immuno, a formulation extracted from five commonly used mushrooms (Turkey Tail, Cordyceps, Reishi, Shiitake, and Agaricus), aims to address this issue. However, the combined influence of these mushrooms on the immune system is poorly understood. To explore this, we conducted a series of studies evaluating the effect of the treating with this formulation on LPS-induced inflammation. Methods: C57Bl/6 male and female mice (n = 7 per group) were challenged with or without LPS. After the challenge, they were divided into eight groups. Four groups received 1 drop of Natures Immuno twice daily for 5 days, while four groups acted as a control. Inflammatory differences were compared in blood, bronchoalveolar lavage fluid, and lung tissue samples at the end of the treatment periods. Results: Lung inflammatory markers in Natures Immuno-treated mice were significantly lower than in LPS-treated mice. Conclusions: These findings suggest that treatment with these five mushrooms may assist in supporting the immune system against LPS-induced inflammation.