Elucidating the association between single nucleotide polymorphisms and microbial diversity in breast carcinogenesis

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Presentation Time: 03:15 PM - 04:30 PM
Poster Board Number: B818
Abstract ID: 4806

Presenting Author:
Carter Fleming , Student at Western Reserve Acad.

Abstract:

Breast cancer, a major global health issue, is marked by high morbidity and mortality. Our research, involving genome-wide sequencing data from 440 female breast cancer patients, aimed to dissect its genetic foundations. We integrated traditional genomic analysis on chromosome 1 with 16S rRNA Gene Sequencing data to examine the breast cancer microbiome. This comprehensive dual-method analysis revealed over 3,000 significant single nucleotide polymorphisms (SNPs) alongside a diverse community of various bacterial genera. Remarkably, 38% of these SNPs were non-coding transcript exon variants, and 30% were intron variants. Our results demonstrate a correlation between genetic mutations and the microbiome in breast cancer, underscoring an intricate interaction between an individual's genetic makeup and microbiome composition. This interplay can influence disease development, progression, and treatment response, highlighting the potential for more personalized therapies. Emphasizing a holistic approach, our study shows the importance of integrating genetic and microbial diversity to fully comprehend breast cancer's complexity and pave the way for innovative treatment strategies.