Controlled Reduction of Reactogenicity in Vaccines - Designing New Molecules to Alter Innate Signal Processing

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Presentation Time: 02:15 PM - 03:30 PM
Poster Board Number: B196
Abstract ID: 6064

Presenting Author:
Aaron Esser-Kahn , Professor at Univ. of Chicago Pritzker Sch. of Molecular Engr.

Abstract:

Vaccines are a critical tool in preventing and managing many diseases, but their efficacy can be improved by enhancing their immunogenicity and lowering their reactogenicity. We have developed a series of molecules that directly reduce correlates of reactogenicity while also improving protection. We present data on the application of these immunomodulator towards a CpG adjuvanted subunit SARS- CoV-2 vaccine in both mice and Syrian hamsters. Immunomodulator-containing vaccines increased neutralizing antibody and T-cell responses in mice. In a challenge model in hamsters, these vaccines reduced weight loss, viral load, and tissue damage. These findings demonstrate the possible improvement of current and future vaccines using immunomodulators. We also present a series of modulators that reduce and direct inflammatory responses in a controlled fashion for use in influenza, hepatitis, typhoid, and many other vaccine applications.