The polyphenols rich extract from Aruncuse dioicus ameliorates hyperglycemia and insulin resistance in high fat and STZ induced type 2 diabetic mice
Presentation Time: 11:30 AM - 12:45 PM
Poster Board Number: B523
Abstract ID: 4841
Presenting Author:
sihoon park , Graduate student at Chosun Univ.
Abstract:
Type 2 diabetes (T2D) is caused by dysfunctional glucose regulation resulting from a decline in β cell insulin secretory function and multi-organ insulin resistance. The aim of study is to investigate the effects of Aruncus dioicus extract (ADE) on T2D and intracellular glucose uptake and in vivo and in vitro. 6-weeks C57BL/6 mice were randomly divided into five groups; normal control (NC) with 11 kcal% fat; high-fat diet (60 kcal% fat) injected STZ (40 mg/kg i.p) to induce T2D (HF+STZ); diabetic mice treated with 50 mg/kg BW ADE (HF+STZ+LADE) or 200 mg/kg BW ADE (HF+STZ+HADE); and diabetic mice treated with 200 mg/kg BW of Momordica charantia extract (HF+STZ+MCE), known to have anti-diabetic effects, was used as a positive control. The extracts were administered orally for 6 weeks. The HF+STZ group exhibited hyperglycemia and glucose intolerance, as evidenced by elevated HOMA-IR index and increased area under the curve during the glucose tolerance test following STZ treatment. Interestingly, ADE supplementation 1) improved obesogenic parameters and lipid profile and 2) ameliorated glucose intolerance compared to HF+STZ group. ADE exhibited 3) abundant polyphenols with high antioxidant activity, and 4) enhanced intracellular glucose uptake in 3T3-L1 adipocytes and C2C12 myotubes. These results provide significant pharmacological insights supporting the potential use of ADE in the management of T2D.
The polyphenols rich extract from Aruncuse dioicus ameliorates hyperglycemia and insulin resistance in high fat and STZ induced type 2 diabetic mice
Category
Poster and Podium (Block Symposium)