IgA controls enteric virus colonization to preserve intestinal immune homeostasis.

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Presentation Time: 11:30 AM - 12:45 PM
Poster Board Number: B105
Abstract ID: 5110

Presenting Author:
Wioletta Lisicka , PhD Candidate at Univ. of Chicago

Abstract:

Immunoglobulin A (IgA) is the predominant immunoglobulin isotype in mammals, primarily secreted at mucosal surfaces. Within the intestinal lumen, secretory IgA forms a protective barrier around a diverse array of commensal microbiota, yet its precise role has remained enigmatic. In this study, we elucidate the pivotal role of T cell-dependent IgA in preventing chronic infection by specific enteric viruses, thereby upholding mucosal immune equilibrium. IgA deficiency leads to persistent enteroviral colonization and a consequential expansion of intraepithelial CD8αβ T cells, characterized by their classic restriction and priming by Batf3-dependent cDC1s. Moreover, IgA protects hosts from colitis in IL-10 deficient background or after DSS administration. The development of colitis in IgA deficient hosts is virus dependent. These findings shed light on the specific mechanism through which IgA orchestrates the control of select enteric viruses, safeguarding intestinal immune tolerance and shielding the host from immunopathological consequences.