Evaluating fenbendazole's cytotoxic impact on malignant cell viability

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Presentation Time: 11:30 AM - 12:45 PM
Poster Board Number: B153
Abstract ID: 4811

Presenting Author:
Phalak Dhingra , Student at Western Reserve Acad.

Abstract:

Introduction: This study explores fenbendazole's anticancer potential, focusing on its effects on cancer cell proliferation and survival. The aim is to determine fenbendazole's efficacy as an oncologic agent by assessing its impact on cancer cell viability.

Objectives: The main objective is to evaluate fenbendazole's cytotoxic effects on malignant cells, examining its pharmacodynamic properties and antineoplastic mechanisms.

Methods: Cancer cell lines were cultured to 80% confluence. After counting, cells were seeded in 24-well plates and treated with various fenbendazole concentrations. Controls were set for comparison. Post-treatment, cell morphology, cytotoxicity, and viability were monitored. Viability was quantified using the Trypan Blue exclusion method.

Results: Results showed significant reduction in cancer cell viability with fenbendazole treatment. Viability assays indicated a dose-dependent cytotoxic effect, suggesting fenbendazole's potential as a therapeutic agent in oncology.

Conclusions: This study confirms fenbendazole's promise as an anticancer agent. Its ability to induce apoptosis in cancer cells supports its further investigation in preclinical and clinical trials, potentially expanding the range of anticancer treatments.