The Effect of Hypomagnetic Field on C. elegans Development, Lifespan and Innate Immune Responses

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Presentation Time: 11:30 AM - 12:45 PM
Poster Board Number: B1031
Abstract ID: 4744

Presenting Author:
Alexis Montana , Student at St. Joseph's University, New York

Abstract:

Advances in space exploration have enticed questions about human interplanetary travel. The magnetic fields of Mars and Moon are almost non-existent compared to Earth’s and space in between has none. Therefore, it is important to study the impact of the hypomagnetic field (HMF) on multicellular organisms before any interplanetary missions take place. 

In this research we used Caenorhabditis elegans (C. elegans) as a model organism. The nematode is easy to grow, analyze, and it has a well characterized genome and innate immune system. C.elegans were grown under control and HMF conditions and then were exposed to different tests, like increased heat and induced oxidative stress (OSS). Worms grown under HMF conditions and exposed to heat stress showed a 30% increased survival rate in comparison to worms grown in a control environment. During the OSS experiment 20% of HMF worms were alive after 40 minutes of incubation time while no control worms survived at that point. The results also demonstrated HMF negatively impacts fecundity causing the organism to produce fewer eggs and offspring, as well as grow relatively smaller in size. Also, the HMF worms consistently had a 50% lower motility rate than the control groups. 

Thus, preliminary data showed that HMF exposed C.elegans had increased rate in stress responses and longevity while reduced reproductive capacity, size and fitness.  More research needs to be done to understand a broader impact of HMF on multicellular organisms.