Extent of immune history shapes the antibody response against the influenza virus in a mouse model

(P141)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 141
Abstract ID: 4274

Presenting Author:
Huibin Lyu, Univ. of Illinois, Urbana-Champaign

Co-Authors:
HUIBIN LYU, Univ. of Illinois, Urbana-Champaign; Qi Wen Teo, Univ. of Illinois, Urbana-Champaign; Chang-Chun D. Lee, Scripps Res.; Weiwen Liang, Univ. of Hong Kong; Danbi Choi, Univ. of Illinois, Urbana-Champaign; Kevin J Mao, Univ. of Illinois, Urbana-Champaign; Roberto Bruzzone, Univ. of Hong Kong; Ian A. Wilson, Scripps Res.; Nicholas C. Wu, Univ. of Illinois, Urbana-Champaign; Chris K. P. Mok, Chinese Univ. of Hong Kong;

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Co-evolution of antibody responses against human immunodeficiency virus (HIV-1) envelope

(P143)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 143
Abstract ID: 4432

Presenting Author:
Juhi Arora, Henry M. Jackson Fndn. for the Advancement of Mil. Med., Walter Reed Army Institute of Research (WRAIR), U.S. Military HIV Research Program (MHRP)

Co-Authors:
Kevina Birungi, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Chaim A Schramm, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Timothy S Johnston, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Amy R Henry, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Sarah E Nortelus, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Sari Jacob, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Michelle Zemil, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Erin Kavusak, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Mekhala Rao, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Gabriel Smith, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Eric Lewitus, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Meera Bose, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Eric Sanders-Buell, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Morgane Rolland, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Victoria R Polonis, Walter Reed Army Institute of Research (WRAIR), U.S. Military HIV Research Program (MHRP); Daniel C Douek, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH; Sandhya Vasan, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Merlin A Robb, Henry M. Jackson Fndn. for the Advancement of Mil. Med.; Shelly J Krebs, Walter Reed Army Institute of Research (WRAIR), U.S. Military HIV Research Program (MHRP); Nicole Doria-Rose, National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), NIH;

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B cell derived IL-1β is required for germinal center function

(P145)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 145
Abstract ID: 4909

Presenting Author:
Juliana Restrepo, Penn State Univ. Col. of Med.

Co-Authors:
Cainan Riccio-Baum, Penn State Univ. Col. of Med.; S. Rameeza Allie, Penn State Univ. Col. of Med.;

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B and T cell repertoire and gene expression differences in measles infection and vaccination revealed by longitudinal single-cell RNA/VDJ sequencing

(P147)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 147
Abstract ID: 4752

Presenting Author:
Kwan Pui Chan, Johns Hopkins Bloomberg Sch. of Pub. Hlth.

Co-Authors:
Jessica Rubens, Johns Hopkins Bloomberg Sch. of Pub. Hlth.; Maggie Bartlett, Johns Hopkins Bloomberg Sch. of Pub. Hlth.; Jacqueline Brockhurst, Johns Hopkins Bloomberg Sch. of Pub. Hlth.; Shristi Ghimire, Johns Hopkins Bloomberg Sch. of Pub. Hlth.; Diane Griffin, Johns Hopkins Bloomberg Sch. of Pub. Hlth.;

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Chikungunya-virus-specific CD4⁺ T cells are associated with chronic chikungunya viral arthritic disease in humans.

(P151)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 151
Abstract ID: 4257

Presenting Author:
Rimjhim Agarwal, La Jolla Inst. for Immunol., UCSD

Co-Authors:
James Chang, La Jolla Inst. for Immunol.; Fernanda H Cortes, La Jolla Inst. for Immunol.; Calvin Ha, La Jolla Inst. for Immunol.; John Villalpando, La Jolla Inst. for Immunol.; Izabella N Castillo, Univ. of North Carolina, Chapel Hill; Rosa I Galvez, La Jolla Inst. for Immunol.; Alba Grifoni, La Jolla Inst. for Immunol.; Alessandro Sette, La Jolla Inst. for Immunol.; Claudia M Romero-Vivas, Universidad del Norte; Mark T Heise, Univ. of North Carolina, Chapel Hill; Lakshmanane Premkumar, Univ. of North Carolina, Chapel Hill; Andrew Falconar, Universidad del Norte; Daniela Weiskopf, La Jolla Inst. for Immunol.;

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Activation induced upregulation of CD4 increases permissibility of Vδ1 T cells to latent HIV-1 infection.

(P153)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 153
Abstract ID: 4614

Presenting Author:
Brendan Mann, George Washington Univ. Sch. of Med. and Hlth. Sci.

Co-Authors:
Marta Sanz; Kayley Langlands; Claire Deleage; Marc Siegel; Natalia Soriano-Sarabia;

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The CD40/CD40L dyad, an immune checkpoint regulator, plays a protective role against Mouse hepatitis virus-induced neuroinflammatory demyelination

(P155)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 155
Abstract ID: 4389

Presenting Author:
Jayasri Das Sarma, Indian Inst. of Sci. Edu. and Res., Kolkata, Penn Med.

Co-Author:
Bishal Hazra, Indian Inst. of Sci. Edu. and Res., Kolkata;

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Frequency of Dengue Virus-Specific T Cells is related to Infection Outcome in Endemic Settings

(P157)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 157
Abstract ID: 4644

Presenting Author:
Daniela Weiskopf, La Jolla Inst. for Immunol.

Co-Authors:
Rosa Isela Galvez, La Jolla Inst. for Immunol.; Amparo Martinez-Perez, La Jolla Inst. for Immunol.; E. Alexandar Escarrega, La Jolla Inst. for Immunol.; Tulika Singh, Univ. of California, Berkeley; Jose Victor Zambrana, Univ. of Michigan; Angel Balmaseda, Sustainable Sci. Inst., Managua; Eva Harris, Univ. of California, Berkeley;

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First lung infection permanently enlarges LN and enhances new T cell responses

(P159)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 159
Abstract ID: 5961

Presenting Author:
Michael Stolley, Univ. of Minnesota Med. Sch., Lerner Res. Inst., Cleveland Clin.

Co-Author:
David Masopust, Univ. of Minnesota Med. Sch.;

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Neurotropic viral infections induce priming and maintenance of a novel antigen-specific CD8 T cell population within the bone marrow that dysregulates the stem cell niche upon reactivation

(P163)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 163
Abstract ID: 5932

Presenting Author:
Rachael A Reesman, Duke Univ.

Co-Authors:
Delaney M Wolf, Duke Univ.; Zachariah P Tritz, Mayo Clin., Minnesota; Christian K Pfaller, Mayo Clin., Minnesota; Alexandra M Hoyt-Miggelbrink, Duke Univ.; Michael J Hansen, Mayo Clin., Minnesota; Cori E Fain, Mayo Clin., Minnesota; Aaron J Johnson, Mayo Clin., Minnesota; Katayoun Ayasoufi, Duke Univ.;

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HMGB2 regulates virus-specific CD8⁺ T cell differentiation and function.

(P165)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 165
Abstract ID: 4379

Presenting Author:
Jamie-Jean De La Torre, Univ. of California, Irvine, Univ. of California, Irvine, Chao Family Comp. Cancer Ctr.

Co-Authors:
Emily Neubert, Univ. of California, Irvine; Karla Viramontes, Univ. of California, Irvine; Melissa Thone, Univ. of California, Irvine; Monique Henriquez, Univ. of California, Irvine; Roberto Tinoco, Univ. of California, Irvine;

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Heterogeneity of EBV-specific CD8 T-cell immunity in tissues is based on epitope specificity.

(P167)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 167
Abstract ID: 4530

Presenting Author:
Julien Gras, Columbia Univ. Irving Med. Ctr.

Co-Authors:
Isaac J Jensen, Columbia Univ. Irving Med. Ctr.; Julia Davis-Porada, Columbia Univ. Irving Med. Ctr.; Donna Farber, Columbia Univ. Irving Med. Ctr.;

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Age influences CMV-specific NK and CD8 T cell memory fates

(P169)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 169
Abstract ID: 5503

Presenting Author:
Isaac Jensen, Columbia Univ. Irving Med. Ctr.

Co-Authors:
Benjamin J Redenti, Columbia Univ. Irving Med. Ctr.; Joshua Gray, Columbia Univ. Irving Med. Ctr.; Daniel Caron, Columbia Univ. Irving Med. Ctr.; Donna Farber, Columbia Univ. Irving Med. Ctr.;

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The role of CMKLR1 in lymphocyte activation and localization within the CNS during West Nile Virus Encephalitis

(P171)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 171
Abstract ID: 6077

Presenting Author:
Alejandro Cortes, Cal Poly, Pomona

Co-Author:
Douglas Durrant, Cal Poly, Pomona;

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Improving immunity against chronic virus infection using an autoimmunity associated Ptpn22 allele.

(P173)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 173
Abstract ID: 5441

Presenting Author:
Anam F Shaikh, Univ. of Kansas

Co-Authors:
Alec Bevis, Univ. of Kansas; Jenna Barnes, Univ. of Kansas; Nancy Schwarting, Univ. of Kansas; Tammy Cockerham, Univ. of Kansas; Robin C Orozco;

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Elevation of systemic lipids during persistent viral infection modulates a stem-like population of exhausted T cells and leads to enhanced viral clearance

(P175)

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Presentation Time: 11:30 AM–12:45 PM
Posterboard Number: 175
Abstract ID: 6015

Presenting Author:
Katelynn R Kazane, UCSD

Co-Authors:
Lara Labarta-Bajo, Salk Inst. for Bio. Sts.; Fernando Vargas, UCSD; Kelly C Weldon, UCSD; Pieter C Dorrestein, UCSD; Elina I Zuniga, UCSD;

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